نام آزمایش : GCDFP-15 (IHC)
هزینه آزمایش : 0 ریال
وضعیت ارائه آزمایش : موجود
نوع نمونه :
Tissue Acceptable: Formalin-fixed, paraffin-embedded tissue block
حجم نمونه :
2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
اطلاعات بالینی :
Immunohistochemical staining with the monoclonal antibody gross cystic disease fluid protein 15 (GCDFP-15) produces diffuse, granular cytoplasmic staining in apocrine sweat glands, normal breast epithelial cells, and breast carcinoma malignant cells. Other neoplasms expressing GCDFP-15 are extramammary Paget disease and carcinomas of the salivary glands, sweat glands, and prostate. A heterogeneous staining pattern, often with paranuclear enhancement, is usually obtained in breast carcinoma.USEFUL FOR
Gross cystic disease fluid protein 15 (GCDFP-15, syn. prolactin-inducible protein, PIP) is a 15 kDa protein that was originally detected in the cystic fluid from cystic mastopathy. It is not expressed in normal ductal or lobular epithelium but in apocrine metaplasia of the breast . Apart from breast cancer, only very few tumors, such as prostate cancer and carcinomas of the skin appendages express GCDFP-15 . It is therefore highly specific for mammary differentiation in females, and is frequently used as an immunohistochemical marker for the evaluation of a potential mammary origin of metastatic carcinoma of unknown primary site. The expression of GCDFP-15 is regulated by the androgen receptor (AR)