آزمایشگاه پاتوبیولوژی راز

Test name: INI_1 (IHC)

Test cost: 0 Rial

Status of test presentation: Existing

Sample type:

Tissue

Formalin-fixed, paraffin-embedded tissue block

Sample size:

2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Clinical information:

Integrase interactor 1 (INI1) is a member of the SWI/SNF (SWItch/sucrose non-fermentable) chromatin remodeling complex, which play an important role in regulation of transcription by modulating access of protein to DNA. Loss of function of these complexes has been implicated in human cancers. Point alterations and deletions of the INI BAF47 gene may be seen in pediatric rhabdoid tumors, rhabdomyosarcoma, chronic myeloid leukemia, and in central nervous system tumors (medulloblastomas and choroid plexus carcinomas) where loss of nuclear staining for INI1/BAF47 is seen. In normal tissues, nuclear expression of INI1/BAF4 should be present in all cell types.

Similar names:

Integrase interactor 1 (INI1)

BAF47

Intervening factors:

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Cases of non-acceptance of samples:

Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides

Test INI_1 (IHC)