Test cost: 0 Rial

Status of test presentation: Existing

Sample type:

Tissue

 Formalin-fixed, paraffin-embedded tissue block

Sample size:

 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

 

Clinical information:

Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma(HCC).

Hepatocyte Specific Antigen (HSA) is considered specific for normal and neoplastic hepatocytes . Expression has been demonstrated consistently in the majority of hepatocellular carcinomas . Studies have shown HSA can be used in a panel with Glypican-3, CEA, CK7, AFP and CD10

Intervening factors:

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Cases of non-acceptance of samples:

Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides