آزمایشگاه پاتوبیولوژی راز

Test name: GCDFP-15 (IHC)

Test cost: 0 Rial

Status of test presentation: Existing

Sample type:

Tissue

Acceptable: Formalin-fixed, paraffin-embedded tissue block

Sample size:

2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Clinical information:

USEFUL FOR

Aiding in the identification of extramammary Paget disease, carcinomas of the salivary glands, sweat glands, and prostate.

Immunohistochemical staining with the monoclonal antibody gross cystic disease fluid protein 15 (GCDFP-15) produces diffuse, granular cytoplasmic staining in apocrine sweat glands, normal breast epithelial cells, and breast carcinoma malignant cells. Other neoplasms expressing GCDFP-15 are extramammary Paget disease and carcinomas of the salivary glands, sweat glands, and prostate. A heterogeneous staining pattern, often with paranuclear enhancement, is usually obtained in breast carcinoma.

Gross cystic disease fluid protein 15 (GCDFP-15, syn. prolactin-inducible protein, PIP) is a 15 kDa protein that was originally detected in the cystic fluid from cystic mastopathy. It is not expressed in normal ductal or lobular epithelium but in apocrine metaplasia of the breast . Apart from breast cancer, only very few tumors, such as prostate cancer and carcinomas of the skin appendages express GCDFP-15 . It is therefore highly specific for mammary differentiation in females, and is frequently used as an immunohistochemical marker for the evaluation of a potential mammary origin of metastatic carcinoma of unknown primary site. The expression of GCDFP-15 is regulated by the androgen receptor (AR)

Test GCDFP-15 (IHC)

USEFUL FOR