Test cost: 0 Rial

Status of test presentation: Existing

Sample type:

Tissue

Formalin-fixed, paraffin embedded (FFPE) tissue block

Clinical information:

• Myogenin is a member of a family of myogenic regulatory proteins which includes MyoD, myf5 and MRF4
• There genes encode transcription factors essential for muscle development
• Expression of Myogenin is restricted to cells of skeletal muscle origin
• Nuclear expression of myogenin is inversely related to the degree of cellular differentiation of rhabdomyosarcoma tumor cells

 

Useful for:  

• Myogenin has been detected in the majority of routinely processed rhabdomyosarcomas and Wilms tumors
• Myogenin is useful in a panel of immunostains (or frozen and/or paraffin sections) to evaluate small blue round cell tumors and poorly differentiated sarcomas
• No immunoreactivity has been observed in Ewing's sarcoma/pPNET or in neuroblastomas
• Myogenin will stain the nuclei of myoblasts from human fetal limbs, however no reactivity is observed in adult skeletal muscle
• Myogenin has not stained leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, malignant fibrous histiocytoma, synovial sarcoma and malignant peripheral nerve sheath tumor in the small number of reported cases 

Name of measurement method:

Immunohistochemistry (IHC)

Cases of non-acceptance of samples:

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair