عنوان:

مجمع راز الطبي، شارع المجال الغربي، شيراز

رقم التليفون:

071-91009393

ساعات العمل:

السبت إلى الأربعاء 6 إلى 24:00، الخميس 6 إلى 19 والعطلات 7 إلى 12:30

فحص GCDFP-15 (IHC)

اسم الاختبار: GCDFP-15 (IHC)

تكلفة الاختبار: 0 ریال

حالة عرض الاختبار: موجود

نوع العينة:

Tissue

Acceptable: Formalin-fixed, paraffin-embedded tissue block

 

حجم العينة:

2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

المعلومات السريرية:

USEFUL FOR 

Aiding in the identification of extramammary Paget disease, carcinomas of the salivary glands, sweat glands, and prostate.

Immunohistochemical staining with the monoclonal antibody gross cystic disease fluid protein 15 (GCDFP-15) produces diffuse, granular cytoplasmic staining in apocrine sweat glands, normal breast epithelial cells, and breast carcinoma malignant cells. Other neoplasms expressing GCDFP-15 are extramammary Paget disease and carcinomas of the salivary glands, sweat glands, and prostate. A heterogeneous staining pattern, often with paranuclear enhancement, is usually obtained in breast carcinoma.

Gross cystic disease fluid protein 15 (GCDFP-15, syn. prolactin-inducible protein, PIP) is a 15 kDa protein that was originally detected in the cystic fluid from cystic mastopathy. It is not expressed in normal ductal or lobular epithelium but in apocrine metaplasia of the breast . Apart from breast cancer, only very few tumors, such as prostate cancer and carcinomas of the skin appendages express GCDFP-15 . It is therefore highly specific for mammary differentiation in females, and is frequently used as an immunohistochemical marker for the evaluation of a potential mammary origin of metastatic carcinoma of unknown primary site. The expression of GCDFP-15 is regulated by the androgen receptor (AR)


عنوان: مجمع راز الطبي، شارع المجال الغربي، شيراز

أرقام الاتصال: 071-32369393-6 / 071-91009393

ساعات العمل: السبت إلى الأربعاء 6 إلى 24:00، الخميس 6 إلى 19 والعطلات 7 إلى 12:30


رقم الواتس اب : 09914444130
عنوان الانستقرام: instagram.com/razlab.ir